الملخص

Background

Various agents have been used to accelerate the rate of cervical dilatation with subsequent reduction in the duration of labor, thus preventing prolonged labor.

Study Objectives

To evaluate the efficacy of intramuscular Hyoscine Butyl Bromide in shortening the active phase of the first stage of labor total duration of labor among primigravida women at Al-Gomhory Hospital, Taiz, Yemen (from January to December 2025).

Study Design

A prospective, interventional, comparative study.

Methods and Materials

A questionnaire was constructed for this study, including all information about the mother, such as age, gestational age, place of residence, antenatal check-up, cervical condition, mode of delivery, and maternal and neonatal outcomes. Cases were divided into two groups: the study group (n = 51) was given 20 mg of hyoscine intramuscularly when the laboring women in the active phase of the first stage (cervix dilated between 4 and 8 cm), while the control group (n= 51) was not given any drug. Data was collected for both groups, and the cases were followed up until delivery. The information was recorded and entered into SPSS Microsoft program for analysis.

Results

The mean age of women in the study group was 22.22±4.58 years, and in the control group, 22.29±4.1 years. There was no statistically significant differences between the two groups. There were also no statistically significant differences in place of residence, as the majority of both groups were urban residents. There were 74.5% of the study group did not visit the antenatal care clinic during pregnancy, compared to 72.5% of the control group.

One-third of the study group delivered prematurely (between 35 and 37 weeks), and the remaining two-thirds delivered at term. There was no statistically significant differences between the two groups in relation to gestational age at delivery, nor was any statistical differences between the two groups in cervical dilatation and cervical position at the time of giving hyoscine butyl bromide. Almost all of the two groups delivered spontaneously vaginally, with the exception of one case in the study group in which forceps was used. Maternal complications included postpartum hemorrhage (1.9%) and perineal laceration (5.9%). There were no statistically significant differences between the two groups in terms of the Apgar score, birth weight, or admission to postpartum intensive care.

The study showed that the use of hyoscine resulted in a significant reduction in the duration of the active phase of the first stage of labor compared to the control group. The study also showed that the drug did not shorten the duration of the second stage of labor, while it reduced the duration of the third stage of labor and also reduced the overall duration of labor compared to the control group. The study did not observe any increase in the amount of bleeding during labor between the two groups.

 Conclusion

The study showed that the use of hyoscine butyl bromide resulted in a statistically significant acceleration in the duration of the active phase of the first stage of labor, but no acceleration in the second stage of labor. However, a statistically significant acceleration in the duration of the third stage was observed, and the overall duration of labor was reduced compared to the control group. The study did not observe any complications from the drug used for mothers or newborns, and postpartum bleeding was minimal, indicating that this drug is safe and effective.